Lionel Messi came off the bench to score a hat-trick in just 18 minutes on Friday as Argentina hammered Panama 5-0 and eased into the quarter-finals of the Copa America. Argentina were 1-0 up at half-time thanks to a Nicolas Otamendi goal after just six minutes. Panama lost Anibal Godoy to a red card after half an hour but the Central Americans held on until Messi, who missed Argentina's opening win against Chile with a sore back, replaced Augusto Fernandez after 61 minutes. The Barcelona forward started gingerly but grabbed Argentina's second in the 68th minute by steering home a left foot shot after a rebound fell to him in the Panama box.